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A Guide to AMPK Activators

AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.

ATP is actually the most significant energy molecule present in the body. Simply put, this is where cellular function all begins. ATP breaks down into ADP that has less potential for energy since the cells are using energy. ADP is broken down to AMP containing the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.

There are different mechanisms in which AMPK acts on. This makes sense since AMPK is the master regulator of all functioning cells. The impact of AMPK activation in our body will depend on a complicated balance of both factors as well as signaling pathways. In the end, you are sure to reap plenty of benefits from improved AMPK activation like:

Anti aging – AMPK activation is gradually declining as we are aging. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. This promotes cellular renewal and at the same time, production of new mitochondria.

Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.

Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.

There are lots of herbal products/constituents and nutritional products too that are proven to be effective as AMPK activator and few of these are:

Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.

Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.

Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.

Number 4. Berberine – not just that it is an AMPK activator, it has berberine containing metformin which is great for anti-diabetes.

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